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In TRIUMPH-4, participants with obesity and knee osteoarthritis taking retatrutide 12 mg lost ~28.7% of body weight (~71 lbs at 68 weeks) and saw substantial improvements in pain and function: WOMAC pain scores reduced by 4.5 points (75.8%) Meaningful gains in physical function, with many patients essentially free of knee pain by study end If these results are confirmed in broader use, were not just talking about weight loss drugs anymorewere talking about disease-modifying therapies that simultaneously target obesity, pain, mobility, and downstream CV risk
The rate of new side effects dropped to near zero
Comparison is the thief of joy. This quote is attributed to Teddy Roosevelt, sage wisdom that we may all do well to adopt into a weight loss mindset
Drinking plenty of water and eating a balanced diet with fiber can help manage diarrhea
The roles of melatonin in development
NCT04184622
