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Trulicity offers powerful A1C reduction 1 Primary endpoint: Mean A1C reduction at 36 weeks (mean baseline A1C: 8.6%) Mean duration of diabetes: 7.6 years 1 Adult dosage: Recommended starting dosage is 0.75 mg injected subcutaneously once weekly

When to seek medical attention: Severe or persistent abdominal pain (stop medication and seek urgent carepotential pancreatitis) Persistent nausea or vomiting affecting hydration or nutrition Signs of gallbladder disease (right upper quadrant pain) Symptoms of hypoglycaemia if taking other diabetes medications No weight loss after 3 months at maintenance dose Regular monitoring, including weight, waist circumference, blood pressure, and metabolic parameters, should be conducted throughout treatment to assess efficacy and safety

Their effectiveness in sustained weight loss has made them a popular choice in the medical weight loss space

We also need to differentiate the isolated effects of GLP-1 receptor agonists on male sexual health from the [effects from] weight loss. For more information: Adnan Ezici , MD, can be reached at [email protected].

doi: 10.1016/S2213-8587(19)30192-5 32 HusainMBirkenfeldALDonsmarkMDunganKEliaschewitzFGFrancoDRet al

Those with a history of pancreatitis need careful evaluation before starting