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Generation of KO and knockdown cell lines Optimized sgRNA oligonucleotides 64 were cloned into lentiCRISPRv2 (ref

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The results found the IGF-1 phase to be associated with improvement in social impairment and restrictive behaviors [14]

The cells were treated with 10 mM EtGSH in FluoroBrite DMEM for 34 h, 1 mM BSO in FluoroBrite DMEM for 34 h, 1 mM H 2 O 2 for 20 min in FluoroBrite or vehicle (FluoroBrite DMEM)

*Backed by results from real skin analysis panelists