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Do not remove and re-insert the needle multiple times, as each puncture creates a potential contamination pathway

Therefore, patients should anticipate continued expenditures

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Nakamura M, Matsumoto H, Nakashima H, et al

Moreover, hydroquinone-loaded NLCs significantly improved skin penetration and UVA/UVB radiation protection in comparison to the hydroquinone conventional formulation (Wu et al., 2017)