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Adding tesamorelin may provide incremental benefits for visceral fat and muscle preservation, but those benefits come with significant unknown risks
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In the retatrutide trial data above, dysesthesia jumped from 8.8% at the 9 mg dose to 20.9% at the 12 mg dosea pattern that mirrors whats been seen with another GLP-1 medication at a higher dose
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They can also help to improve skin health, increase strength and endurance, and enhance cognitive function
Severe caloric restriction and significant body composition changes may trigger hypothalamic amenorrhea, where the brain suppresses reproductive hormone production in response to perceived energy deficit
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