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Indeed, in 23 patients out of a total of 25, 5-MTHF in CSF was low despite normal serum folate treatment with folinic acid for a year restored folate levels and led to clinical improvements

doi: 10.1111/dom.12932 24

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Stability, sensitivity to preservatives, and how often you'll draw from the vial all affect which diluent makes sense for a given compound

Tumour Biology 37: 26472653

The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg