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The clinical case for combining AOD-9604 with GLP-1 therapy in patients who have plateaued is mechanistically coherent (the two compounds act on different sides of the energy balance equation through non-overlapping mechanisms) and is not supported by randomized controlled trial evidence for the specific combination
In the other 50 with gut issues
The medication is available under three brand names: Ozempic, Wegovy, and Rybelsus
We also examine the real question of long-term safety
It works by blocking an enzyme called NNMT (nicotinamide N-methyltransferase)
PMID: 40789979 | doi:10.1007/s12178-025-09990-7 DeFoor MT et al
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