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Concerns about muscle loss with aggressive weight reduction are also relevant here
These opposing effects might seem like they would cancel each other out
In the SURMOUNT-5 trial, tirzepatide (Zepbound) resulted in significantly greater weight loss than semaglutide (Wegovy) in adults with obesity and no history of diabetes
Real-world evidence from UK and European databases suggests that patients with type 2 diabetes and fatty liver who receive GLP-1 therapy experience improvements in liver enzyme levels (ALT, AST) and non-invasive markers of fibrosis
Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 2008
The organization's endorsement follows similar policy shifts in other jurisdictions where health authorities have expanded access to GLP-1 therapies
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