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Additionally, GHK-Cu appears to regulate the TGF-/SMAD pathway a critical pathway involved in fibrosis (pathological scarring of organs)
All these side effects are temporary and relatively minor
It means the evidence is not yet strong enough to make definitive claims
It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations
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