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Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes

This finding provides reassurance that Retatrutide does not cause disproportionate muscle loss despite its more aggressive weight reduction

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"These benefits reflect important clinical effects on kidney, cardiovascular, and survival outcomes among high-risk patients, particularly given the reassuring safety findings, and support a therapeutic role for semaglutide in this population," the authors write

The metabolic benefits gradually reverse

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