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Materials and methods Animal models In these studies, APOE-TR mice were housed in groups of up to four under standard laboratory conditions at 23 1C, 50 5% humidity, with a 12-h light/dark cycle and access to food and water ad libitum

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The frequency of monitoring should be determined by the healthcare provider based on individual patient factors rather than following a standardized schedule

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Compounded vials are typically kept refrigerated (2-8 C), protected from light because B12 is light-sensitive, and discarded per the compounder's beyond-use date