As versatile therapeutic agents, GLP-1RAs demonstrated their benefits across a range of pain syndromes, including inflammatory nociception, visceral hypersensitivity, neuropathic pain, diabetic peripheral neuropathy (DPN), cancer pain and headaches (Fig
Currently, the most popular GLP-1s available in the UK are Mounjaro and Wegovy
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Because the published Phase 2 pharmacology characterizes it as having comparable potency at all three receptors rather than being a single-receptor compound with weak off-target activity
Slower gastric emptying and full-feeling often result in less eating and can ultimately lead to weight loss
Loose skin was pronounced