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In between-drug comparisons, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 4.60 kg [95% CI 7.94, 1.26]), 1.0 mg (MD = 3.53 kg [95% CI 4.80, 2.25]) and 0.5 mg (MD = 2.75 kg [95% CI 4.23, 1.28]), respectively (ESM Table 11)
The association between obesity and altered sense of taste certainly requires further research, but might be a promising target for the modulation of food preferences and overeating
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Gastrointestinal bleeding, ulcer disease, and hemorrhagic stroke remain clinically significant risks, particularly in older adults
Changes in gut microbiota control inflammation in obese mice through a mechanism involving Glp-2-driven improvement of gut permeability
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