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Across a large body of randomized trials, creatine plus resistance training produces modestly greater gains in lean body mass and strength than resistance training alone, with effect sizes in the range of about 1 to 2 kg of additional lean mass and 5 to 10% additional strength over 8 to 12 weeks of training compared with placebo

Animal studies have shown potential risks to fetal development, and there is currently limited human data

Springer, US, New York, NY, pp 2127 Hiller F, Besselt K, Deubel S et al (2015) GPx2 induction is mediated through STAT transcription factors during acute colitis

elegans demonstrates that L-Carnitine extends lifespan through mechanisms dependent on SKN-1 and DAF-16, key transcription factors regulating stress response and longevity pathways

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Cai XS, Tan ZG, Li JJ, Gao WH, Li SJ, Li JL, Tang YM, Li HW, Hui HX