Microdosing may be a fit for women who: Are in perimenopause or menopause and experiencing weight changes, increased cravings, or energy dips Want a gentle, adjustable approach to GLP-1 therapy Prefer pairing medication with lifestyle strategies (nutrition, strength training, hormone therapy) Have no major contraindications to GLP-1 medications When Were More Cautious We may recommend holding off or exploring other options if you have: A personal or family history of medullary thyroid carcinoma or MEN2 A history of pancreatitis Significant gastrointestinal disorders that may be worsened by GLP-1 use Protecting Muscle & Metabolic Health While on GLP1 One of the biggest concerns with any weight-management medication is the potential loss of lean muscle mass
References Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Additionally, the diabetic kidney has increased oxygen demand due to increased sodium reabsorption and (single-nephron) hyperfiltration via increased Na + , K + ATPase activity at the basolateral surface of the tubules [13]
However, for many, GLP-1s may help with the consequences of thyroid dysfunction
52 Orforglipron showed to have a pharmacodynamic and safety profile similar to that of injectable GLP-1 which supported continued clinical development
Afterwards, the medication works in the following ways: Semaglutide alters how your brains hunger control center (lateral hypothalamus) regulates appetite