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Free Radic Biol Med 37:755767 Hirst J, King MS, Pryde KR (2008) The production of reactive oxygen species by complex I

difficile) Avoid colonoscopy in toxic megacolon Management Induction of remission: Mildmoderate: 5-ASA (oral rectal) Moderatesevere: Corticosteroids Severe/refractory: Biologics (anti-TNF, anti-integrin, JAK inhibitors) Maintenance: 5-ASA Azathioprine / biologics (if steroid-dependent) Complications Toxic megacolon Severe bleeding Perforation Colorectal cancer (risk with duration & extent) Surgical Indications Refractory disease Dysplasia or carcinoma Toxic megacolon Massive hemorrhage Colectomy is curative Continuous disease, rectum always involved Limited to mucosa Associated with PSC Smoking appears protective (opposite of Crohns) To view or add a comment, sign in Systemic Lupus Erythematosus (SLE) Definition: SLE is a chronic autoimmune disease in which the immune system attacks multiple organ systems, causing inflammation and tissue damage

Recommended dose is 400 ug/day, though one study showed higher success with 800 ug/day (Carrell 2015)

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Expectations need to be realistic as well

IGF-1 LR3 acts downstream and directly activates IGF-1 receptors