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a) reacting compound of formula-8 with compound of formula- 10 in a solvent optionally in presence of a coupling agent and/or a base to provide compound of formula-11, b) reacting compound of formula- 11 with compound of formula- 10 in a solvent optionally in presence of a coupling agent and/or a base to provide compound of formula- 13, c) optionally purifying compound of formula- 13, d) treating compound of formula- 13 with compound of formula- 14 Formula- 14 wherein, 'R 1 is as defined above
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Some patients even subjectively felt they were losing musclewhile on these medications, according to the report
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Moreover, the question arose whether the positive inotropic effect of retatrutide (in the presence of cilostamide) like those of isoprenaline was mediated in part by increasing the current through the L-type calcium cation channel
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