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Mechanism of Action GHK-Cu exhibits a multifaceted mechanism, influencing gene expression, cellular signaling, and copper homeostasis: 2.1 Collagen and ECM Stimulation: GHK-Cu upregulates genes for collagen (types I, III, IV, VII), elastin, and glycosaminoglycans (GAGs) by modulating transcription factors like SP1 and TGF-

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PMID 17464988

The injection of MS275 (a specific class I HDACi) into NAc was found to have a powerful antidepressant effect, suggesting that histone acetylation plays an adaptive role in the stress response 140

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