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In mice lacking SGLT1, the reduction in postprandial glucose response mediated by a single administration of metformin is attenuated, but not in mice lacking glucose transporter 2 (GLUT2)

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Some of these mutations are lethal in males, but in females they include large deletions of G6PD , which are compatible with life thanks to selection for cells in which the active X chromosome has an intact G6PD allele

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