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The key regulatory milestones: FDA Breakthrough Therapy designation for MASH (September 2024) EMA PRIME designation for MASH (November 2023) China NMPA Breakthrough designation (June 2024) Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) fully enrolled, results expected H1 of this year Estimated FDA filing: Late this year at the earliest Estimated FDA approval: Possibly next year, depending on Phase 3 results If Phase 3 results confirm Phase 2 findings, survodutide could reach the market within the next 12-24 months

The trial also followed participants for a further 28 weeks after stopping treatment

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Excessive weight has also become a social issue, causing those who are obese to reach out for any weight loss help they can getwhether or not it is right for them

FDA approves first treatment to reduce risk of serious heart problems in adults with obesity

The body weight of mice and food intake were recorded daily