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Shortage of vitamin B12 can also result in pernicious anemia, which may be due to impaired absorption of vitamin B12 caused by a lack of intrinsic factora substance necessary for the absorption of vitamin B12 in the intestines

TP53 induces ferroptosis primarily by transcriptionally repressing the expression of SLC7A11 ( TP53 lead to a loss of this repression, resulting in sustained SLC7A11 activity and greater cellular resistance to ferroptosis ( 3 KR, which cannot induce cell-cycle arrest, senescence or apoptosis, fully retains the ability to suppress SLC7A11 and trigger ferroptosis under oxidative stress ( The reasons for variable expression of CHAC1 in different cancers are still unclear, but it appears to be critically dependent on TP53 status

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[2] Wright JW, Harding JW