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found that TMAO promoted calcium/phosphate-induced calcification in the vascular smooth muscle cells of rats and human urinary system patients in a dose-dependent manner, and upregulated the expression of bone-related molecules (Runt-related transcription factor2, Runx2, and Bone morphogenetic protein-2, BMP2)

3.6 Metabolomics and proteomics biomarkers Small molecule metabolite remains the center in the study of metabolomics, and modifications in metabolite levels may be the final result of controlling protein expression

(16) "Data clearly demonstrate that GSH supplementation along with antidiabetic treatment helps restore the gut microbiome by enriching beneficial bacteria of healthy gut and reducing significantly the load of pathogenic bacteria" - study authors

doi: 10.1038/ng.686 104 NovikoffAMllerTD

Metabolism 2010;59(8):1190-1199

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