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Multifaceted roles of GLP-1 and its analogs: a review on molecular mechanisms with a cardiotherapeutic perspective
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Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5
The older adults are at higher risk of developing type 2 diabetes
Patients with diabetes seem to have a lower response to GIP regardless of the concentration of the hormone [21]
If you have diabetes, kidney disease, gastrointestinal conditions, are pregnant/breastfeeding, or have specific nutritional requirements, you should follow personalised advice from your prescriber or a registered dietitian
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