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The 0.25 mg starting dose is primarily about tolerability, not therapeutic effect
As follows, GABA production by the microflora in the metabolically active small intestine could conceivably lessen pathogenic autoreactive T-cell responses in gut-associated lymphoid tissue (GALT) and/or pancreatic lymph nodes (117, 122)
No head-to-head Phase 3 trial has been run between retatrutide and tirzepatide yet, so I'm careful not to claim retatrutide's Phase 3 numbers directly outperform tirzepatide's they are cross-trial comparisons
A general alteration of some metabolic pathways related to specific aromatic or sulfur-containing amino acids, lysine and glutamic acid was also deduced from F vs C, and FR vs CR comparisons
Free Radical Res 55(1112):10481061 Lei L, Zhang F, Huang J, Yang X, Zhou X, Yan H, Chen C, Zheng S, Si L, Jose PA, Zeng C (2023) Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-B pathway
doi: 10.1517/14656566.2012.642866 60 FDA Drug Safety Communication
