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Peer review Peer review information Nature Chemical Biology thanks John Bruning, Jordan Pederick and the other, anonymous reviewer(s) for their contribution to the peer review of this work

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Start your intake How Semaglutide Creates Weight Loss in Your Body Semaglutide functions by mimicking glucagon-like peptide-1, a hormone that regulates appetite and blood sugar

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Semaglutide works by mimicking a hormone in the body called GLP-1, which helps to control blood sugar levels and reduce appetite

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Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype

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