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Das BK, Kumar A, Sreekumar SN, Ponraj K, Gadave K, Kumar S, Murali Achary VM, Ray P, Reddy MK, Arockiasamy A (2022) Comparative kinetic analysis of ascorbate (Vitamin-C) recycling dehydroascorbate reductases from plants and humans

Notably, commonly used cell culture media (for example, DMEM, RPMI and F12) contain supraphysiological levels of cystine but lack GSH and cysteinylglycine

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In this study, Clementi et al

But as we age, our natural glutathione levels decline, and that drop doesnt just show up in lab results

This is made even more problematic, given the number of factors that can deplete glutathione levels