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DOI: 10.1016/j.neurobiolaging.2018.03.001
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In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)
Furthermore, it has been observed that Karonudib does not alter the tumor suppressor activity produced by the injection of autologous tumor-infiltrating lymphocytes (TILs) in a patient-derived xenograft (PDX) model of melanoma
Pharmacol Rep 67(3):569580
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