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doi: 10.1111/nmo.12804 196 NasriKJamilianMRahmaniEBahmaniFTajabadi-EbrahimiMAsemiZ

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A review of the structure and function of the central PLA2 toxin family

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Daraxonrasib , made by Revolution Medicines, has changed that: it first binds a scaffolding protein (called Cyclophilin A) and then RAS, which locks it into an inactive state: This mechanism means that Daraxonrasib inhibits many of the major RAS mutations: Pancreatic cancer is addicted to this continuous RAS activity so if its inhibited, tumours should shrink