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In contrast, microdosing tirzepatide schedules modify this pattern in one or more ways: Starting lower than 2.5 mg (e.g., compounded formulations or diluted solutions under medical supervision) Extending titration intervals (e.g., maintaining 2.5 mg for 812 weeks before increasing) Maintaining moderate doses such as 5 mg or 7.5 mg as a long-term maintenance point rather than progressing to 1015 mg Adjusting injection frequency (e.g., every 10 days instead of weekly) While FDA-approved Mounjaro and Zepbound pens cannot be safely divided or altered, specialized compounded preparations were once used for flexible dosing before the FDA restricted compounding in 2025
Compounding means a pharmacy or physician customizes an approved drug to fit an individual patients needs
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