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Real-world evidence shows that patients have already felt the impact of coverage gaps through dose-splitting, financial hardship, or seeking unauthorized alternatives ( [4] ) ( [7] ) though the FDA's crackdown on compounded GLP-1s and manufacturers' significant price reductions are reshaping these dynamics

There is no universal answer, and personal comfort can change as your body, routine, or dose changes

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Rapid titration may offer short-term benefits, but it increases the risk of side effects and treatment discontinuation

Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, et al