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Free radicals and birth defects

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The activated HPA axis is involved in the pathogenesis of depression by damaging neurons and continuing central inflammation

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With sufficient glutathione present, NAPQI is very quickly metabolized into sulfate and cysteine compounds, which are readily excreted through the kidneys.[ref] However, when it isnt neutralized, NAPQI is highly reactive and can cause oxidative stress and damage to the liver cells, hepatocytes, leading to cell death