Still, the contraindication for those with familial MTC or MEN2 persists, as those individuals already are at high risk genetically and were excluded from trials
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GI AEs were detected most frequently, were transient and usually occurred with dose escalation
Its pharmacological interest is as an inhibitor of nicotinamide N-methyltransferase, usually written NNMT
Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Gravina A, Mereu R, et al