Muscle loss during treatment and weight loss can worsen fatigue and reduce physical function
1 GLP-1 receptor agonists are broadly applied in type 2 diabetes mellitus (T2DM) therapy
Clinical eligibility follows FDA labeling for Wegovy and Zepbound: BMI 30+ or BMI 27+ with at least one weight-related comorbidity such as type 2 diabetes, hypertension, dyslipidemia, OSA, or cardiovascular disease
Recent crystal and cryo-EM structures of class B GPCRs have revealed a relatively conserved binding mode of the peptide hormones and similar orientations between the ECD and TMD when fully activated 3,4,5,8,9
Among patients who switched to a different GLP-1 RA medication, they primarily switched to semaglutide labeled for T2D (24.5%) or to tirzepatide labeled for T2D (14.9%)

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