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Acknowledgements This study was supported by the National Natural Science Foundation of China (81925028 and 82230097 to L.L.) and the National Key Research and Development Program of China (2023YFC3404104 to L.L.) and Innovation Capacity Support Program of Shaanxi Province (2024ZC-KJXX-090 to Y.F.)

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October 6, 2024

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The methionine cycle metabolites are further reduced compounding the effects of trisomy 21

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