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Phase 2 and Phase 3 trials leading to FDA approval studied its effects on sexual desire, arousal, and distress in women with HSDD, with statistically significant improvements versus placebo on the Female Sexual Function Index
Notably, SGLT2 inhibitors improve anemia [87,88] and hyperkalemia [89,90], both prevalent complications in CKD and HF
They work by mimicking the GLP-1 hormone produced in the intestine, which stimulates insulin release, reduces glucagon, slows gastric emptying, and promotes feelings of fullness
Apart from the cosmetic angle, many also report improved energy levels, reduced inflammation, and better immune function over time
It keeps the skin hydrating
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders
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