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Extrinsic Factors: Interaction Between Metabolic Pathways/Fluxes and Breast Cancer Metastasis Induced by Hypoxia, Oxidative Stress, Acidosis, and Tumor Microenvironment Hypoxia Hypoxia represents an important characteristic in the TME arising as a mismatch between cellular oxygen consumption and supply (245)

Chronic activation of the HPA axis can lead to adrenal exhaustion and low adrenal hormone levels (Anderson 2008)

Gut microbiotabile acidintestinal farnesoid X receptor signaling axis orchestrates cadmium-induced liver injury

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Gao, K., Wu, Y., Zhang, Y., Dang, P., Xue, H., Li, T., Zhou, M., Wang, L., & Zhu, Y