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Clinical signs of EAE were assessed using the following disease scores: no clinical signs (0), partial tail weakness (0.5), full paralysis of the tail (1), changes in gait or inability to climb (1.5), paralysis of one hind limb (2), paralysis of one hind limb and restraints in second hind limb (2.5), total paralysis of the hind limbs (3), hind limb paralysis and restraints in one fore limb (3.5), tetraparese (4) and moribund animal/death (5)

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