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Although sufficient evidence exists of inflammatory reactions in ALS, the role of inflammation in the selective motor neuron death occurring during disease progression in ALS is still unclear and might depend upon disease stage

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Tirzepatide has direct effects on cholesterol and triglyceride metabolism independent of weight lossit reduces inflammation and optimizes lipid turnover

This indicates that GLP-2, rather than GIP or GLP-1, plays the major role in the early postprandial suppression of bone resorption (89)