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(2010) Neuron Foundational study identifying Spadin as the first endogenous TREK-1 channel blocker derived from sortilin cleavage, establishing the biological basis from which PE22-28 was developed

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Pro tip: Combine with weight training to maximize ATP demand and with mitochondrial-supportive nutrients like CoQ10 and magnesium

Seasonal cycling: Some researchers run one 12-16 week cycle annually, typically in winter when sun exposure is reduced