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A 2025 meta-analysis examining over 142,000 participants found that tirzepatide produced significantly greater weight loss than semaglutide, an average of 4.23% more body weight lost

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You can also read our metformin comparison guides with other medications below: Side effects and risks of metformin and Ozempic together Both medications cause side effects, and taking them together doesn't eliminate those effects, it may combine them in some patients