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The large 2025 meta-analysis quantified this as approximately 63% higher gastrointestinal adverse event rates compared with placebo, and gallbladder disorders were about 26% higher

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Glutathione may enhance the vasodilatory effects of nitrates, which could lead to hypotension

Even at lower doses (4 mg and 8 mg), statistically significant and clinically meaningful weight reductions were observed compared to placebo

Breast, prostate, and other common cancers have also been tracked in clinical trials