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Orforglipron is a small-molecule, nonpeptide GLP-1 receptor agonist in pill form that should be taken once a day

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Pode ser utilizada diariamente, preferencialmente antes dos treinos

For patients who struggle with cravings, large portions, or frequent hunger, semaglutide may make it easier to follow a nutrition plan

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Any change in cannabis use should be discussed with a treating clinician who knows the patient's full psychiatric history and current stability.Why is this study clinically interesting despite its limits?It tests a common clinical observation with objective tasks and a randomized challenge rather than self-report alone, which is a meaningful step even though it remains early evidence.What would stronger future research look like?Longer, prospective studies that track cognition alongside mood, psychosis risk, and substance-use outcomes across repeated cannabis exposure would provide much stronger evidence