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By increasing Nrf2 downregulation and enhancing ROS generation, parthenolide (PN) and its soluble counterpart dimethyl amino parthenolide (DMPN) have been demonstrated to diminish mammosphere development in triple-negative breast cancer (TNBC) cell lines, as well as the survival of mammosphere-derived CSCs, most likely through increased ubiquitination and proteasome degradation (Carlisi et al., 2016)
doi: 10.3945/an.115.008623
The Effects of GLP-1 Agonists on Musculoskeletal Health and Orthopedic Care
