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Interestingly, the presentation of DAPT and BMS appeared to exert the opposite action to TB-500, suggesting that the Notch/NF-B pathways may mediate TB-500s proposed action on angiogenesis

But the federal agency warns that these unauthorized drugs, which are illegal, pose serious health risks, adding that it still needs to evaluate them for safety, efficacy, and quality. They have not been demonstrated, through scientific trials, to provide the health benefits that they claim, according to Health Canada in an April advisory

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Contraindications must also be assessed carefully to ensure safety: Known allergies to ingredients (especially sulfa-containing methionine)