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Fe 2+ overload, ROS accumulation, GSH depletion, LPO, and mitochondrion shrinkage were observed in HSV-1-infected cultured human astrocytes, microglia and murine brains, which are hallmarks of ferroptosis (Xu et al., 2023).The ways of ferroptosis induced by HSV are related to Nrf2, GSH-GPX4 and dihydroorotate dehydrogenase-dihydroubiquione (DHODH-CoQH2) (Mao et al., 2021
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It facilitates the production of lymphocytes, a type of white blood cell involved in immune responses
Some studies show no change in GSH status upon supplementation of oral glutathione (reduced form) in healthy subjects
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