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Beta cells failure may culminate in de-differentiation, mitochondrial dysfunction, ROS production, unfolded protein response (UPR) / endoplasmic reticulum (ER) stress and islet amyloid polypeptide (IAPP) overexpression, followed by glucolipotoxicity and apoptosis [92, 93]
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
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