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Albino AP, Nanus DM, Mentle IR, Cordon-Cardo C, McNutt NS, Bressler J, Andreeff M

Without GPX4 activator, the downstream metabolites of the 5-LOX, 12-LOX, and 15-LOX pathways were markedly elevated after A23187 stimulation ( Figure 4 ), compared to the normal state ( Supplementary Figure S2 )

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The authors suggest that the amount of Acetyl-CoA in the mitochondrion available for esterification of free carnitine was reduced in fasted or energy-restricted animals leading to increased tissue carnitine concentrations while acetylcarnitine levels were reduced [111]