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Glucagon (GCG) receptor: This is the game-changer
Research suggests that the T allele is associated is marked reduction in the activity of the GPx1 enzyme, with some studies showing a 40% reduction in GPx1 activity
If GLP-1s are going to move from metabolic medicine into the worlds of pain and substance use disorders, we should talk about them the way we would talk about any powerful new class: with evidence, not mythology
In total, 1,797 patients (56.5%) had established CV disease without CKD, 354 patients (11.1%) had CKD only, and 544 patients (17.1%) had both CV disease and CKD
Long-term studies also found that rebound weight gain increases cardiovascular risk markers and inflammation levels that had improved during treatment
(9) All of this can be made worse by blood sugar swings, gut irritation and lack of sleep
