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Men should avoid applying it right after shaving if the skin feels irritated

Zheng L, Wang C, Luo T, Lu B, Ma H, Zhou Z, et al

By reducing prostaglandin production, ibuprofen provides effective pain and inflammation relief but simultaneously increases the risk of gastric irritation, ulceration, and bleeding

Neurology 66(2):265267 Herzmann C, Whiting SJ, Thomas M, Byrne P, Johnson MA, Youle M (2008) Pharmacokinetics of acetyl-l-carnitine given in single or multiple doses to HIV-1 Infected patients with toxic peripheral polyneuropathy

But concentrations above 200mg/mL increase injection site discomfort because the solution becomes viscous

Bkdal TA, Borregaard J, Hansen CW, et al