In summary, these studies highlight microglial polarization modulation as a central therapeutic approach in PD, targeting both inflammatory response and iron-dependent oxidative damage to confer neuroprotection
Published 2020 Jan 30
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(A few other, less-invested experts from the FDA were added to the panel after pushback before last weeks meeting
Using this model, authors show that mtDNA depletion leads to mitochondrial dysfunction, reduced ATP production and ROS enhancement, which causes glutathione exhaustion, a known cause of ferroptosis